Endocrine Abstracts

Hypercalcaemia is one of the common cases seen in Endocrine clinics. We report another challenging case of hypercalcaemia. A 43 old Asian man was referred by GP initially in 2011 with asymptomatic hypercalcaemia of 2.87 mmol/L. His past medical history included chronic plaque psoriasis with arthropathy, hypertension, stage 3 CKD, Fatty liver with mild fibrotic change secondary to methotrexate and learning difficulties. Hypercalcamia was thought to be contributed by Dovonex (Ca...

A 49-year-old lady was referred to the endocrine clinic for hypophosphataemia. Apart from tiredness, she had no other symptoms. Past medical history was significant for bronchiectasis, obstructive sleeps apnoea, caudaequina syndrome, migraine and anxiety. She had frequent hospitalisations due to bronchiectasis exacerbations requiring systemic steroids. Usual medications included azithromycin, gabapentin, omeprazole, antacids, laxatives, carbocisteine, fluoxetine, montelukast, ...

Background: The treatment of choice for primary hyperparathyroidism (PHPT) is surgical parathyroidectomy. Cinacalcet is the first calcimimetic approved by European Medicines Agency (EMA) in 2008 for use in patients with PHPT who are not fit for surgery or refuse surgery. British National Formulary (BNF) recommends it for hypercalcaemia in PHPT where parathyroidectomy is inappropriate. The main aim of treatment with cinacalcet is to keep calcium levels at safe levels.<p cla...

A 49 year old lady presented to the hospital unconscious with severe hypoglycaemia. She had type 1 diabetes for 24 years and coeliac disease. She was hypo-unaware and had multiple admissions with DKA and hypoglycaemia over the years. She did not engage in the self-management of diabetes, therefore, insulin was being injected by the carers in the community and by nurses in the hospital. Her erratic and unpredictable glycaemic control was attributed to non-compliance. She admitt...

A 49 year old lady presented to the hospital unconscious with severe hypoglycaemia. She had type 1 diabetes for 24 years and coeliac disease. She was hypo-unaware and had multiple admissions with DKA and hypoglycaemia over the years. She did not engage in the self-management of diabetes, therefore, insulin was being injected by the carers in the community and by nurses in the hospital. Her erratic and unpredictable glycaemic control was attributed to non-compliance. She admitt...

A 73 year old man was admitted to the hospital with a multi-factorial fall. He was otherwise asymptomatic. Past medical history included stage 3 chronic kidney disease (CKD), ulcerative colitis, epidermolysis bullosa and mild cognitive impairment. Examination was unremarkable apart from unilateral leg swelling and deep venous thrombosis was excluded. Investigations showed incidental undetectable magnesium level and severe hypocalcaemia. Potassium level was normal, 25-hydroxy-v...